A-620223 (succinate)

A-620223 succinate (ABT-472) is an orally available poly (ADP-ribose) polymerase (PARP) inhibitor. A-620223 succinate (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1].

Product Specifications

CAS Number

[943650-25-7]

Product Name Alternative

ABT-472

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-620223-succinate.html

Solubility

10 mM in DMSO

Smiles

CCCN(CC1)CCC1C2=NC3=C(C(N)=O)C=CC=C3N2.O=C(O)CCC(O)=O

Molecular Formula

C20H28N4O5

Molecular Weight

404.46

References & Citations

[1]Penning TD, et al. Discovery and SAR of 2- (1-propylpiperidin-4-yl) -1H-benzimidazole-4-carboxamide: A potent inhibitor of poly (ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16 (14) :6965-75.