Ro 0437626

Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM) [1].

Product Specifications

CAS Number

[134362-79-1]

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ro-0437626.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O

Molecular Formula

C27H35N5O4S

Molecular Weight

525.66

References & Citations

[1]Jaime-Figueroa S, et al. Discovery and synthesis of a novel and selective drug-like P2X (1) antagonist. Bioorg Med Chem Lett. 2005;15 (13) :3292-3295.|[2]Harper MT, et al. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P (2X1) receptors, not a novel non-capacitative Ca2+ entry. J Thromb Haemost. 2010;8 (7) :1604-1613.|[3]King BF, et al. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol. 2004;142 (3) :519-530.