AZ 11645373
AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors, AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM[1].
Product Specifications
CAS Number
[227088-94-0]
UNSPSC
12352005
Hazard Statement
H315, H318, H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/az-11645373.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC4=CC=NC=C4)SCC1=O
Molecular Formula
C24H21N3O5S
Molecular Weight
463.51
Precautions
H315, H318, H335
References & Citations
[1]Stokes L, et al. Characterization of a selective and potent antagonist of human P2X (7) receptors, AZ11645373. Br J Pharmacol. 2006 Dec;149 (7) :880-7.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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