AZ 11645373

AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors, AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM[1].

Product Specifications

CAS Number

[227088-94-0]

UNSPSC

12352005

Hazard Statement

H315, H318, H335

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/az-11645373.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC4=CC=NC=C4)SCC1=O

Molecular Formula

C24H21N3O5S

Molecular Weight

463.51

Precautions

H315, H318, H335

References & Citations

[1]Stokes L, et al. Characterization of a selective and potent antagonist of human P2X (7) receptors, AZ11645373. Br J Pharmacol. 2006 Dec;149 (7) :880-7.