MRS2279 (diammonium)

MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a Ki value of 2.5 nM and an IC50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pKb value of 8.05[1][2][3].

Product Specifications

CAS Number

[2387505-47-5]

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mrs2279-diammonium.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=[P](O)(O)OC[C@]1([C@H]2O[P](O)(O)=O)[C@]([C@](N3C4=NC(Cl)=NC(NC)=C4N=C3)([H])C2)([H])C1.N.N

Molecular Formula

C13H24ClN7O8P2

Molecular Weight

503.77

References & Citations

[1]Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y (1) receptor ligands. J Med Chem. 2000;43 (5) :829-842.|[2]Boyer JL, et al, Ravi RG, Jacobson KA, Harden TK. 2-Chloro N (6) -methyl- (N) -methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y (1) receptor antagonist. Br J Pharmacol. 2002;135 (8) :2004-2010.|[3]Wei W, et al. Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release. Bioengineered. 2022 Feb;13 (2) :2346-2359.