SB 706504
SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides -stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD).
Product Specifications
CAS Number
911110-38-8
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-706504.html
Solubility
10 mM in DMSO
Smiles
N=C(NCCNC1=NC(C2=CC=C(F)C=C2C)=C(C=CC(N3C4=C(F)C=CC=C4F)=O)C3=N1)NC#N
Molecular Formula
C24H19F3N8O
Molecular Weight
492.46
References & Citations
[1]Lauren M. Kent, et al. Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'- (2-{[8- (2,6-difluorophenyl) -4- (4-fluoro-2-methylphenyl) -7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl) guanidine (SB706504) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb546299 100 µg
Cytochrome P450 2B6/CYP2B6 Rabbit Polyclonal Antibody
Sign In for Pricing
View Details MBS6206887-01 0.1 mL
IL1B (Interleukin 1, beta, IL-1, IL1-BETA, IL1F2) (MaxLight 490)
Sign In for Pricing
View Details MBS6206887-02 5x 0.1 mL
IL1B (Interleukin 1, beta, IL-1, IL1-BETA, IL1F2) (MaxLight 490)
Sign In for Pricing
View Details