SB 706504
SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides -stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD).
Product Specifications
CAS Number
911110-38-8
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-706504.html
Solubility
10 mM in DMSO
Smiles
N=C(NCCNC1=NC(C2=CC=C(F)C=C2C)=C(C=CC(N3C4=C(F)C=CC=C4F)=O)C3=N1)NC#N
Molecular Formula
C24H19F3N8O
Molecular Weight
492.46
References & Citations
[1]Lauren M. Kent, et al. Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'- (2-{[8- (2,6-difluorophenyl) -4- (4-fluoro-2-methylphenyl) -7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl) guanidine (SB706504) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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