VU0155069 (hydrochloride)

VU0155069 hydrochloride (CAY10593 hydrochloride) is a potent selective phospholipase D (PLD) inhibitor. The IC50 values for PLD1 and PLD2 are 46 and 933 nM, respectively. VU0155069 hydrochloride inhibits migration of human and mouse breast cancer cell lines[1][2].

Product Specifications

CAS Number

[1781834-89-6]

Product Name Alternative

CAY10593 (hydrochloride)

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vu0155069-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C2C=CC=CC2=C1)N[C@@H](C)CN3CCC(N4C5=CC=C(Cl)C=C5NC4=O)CC3.Cl

Molecular Formula

C26H28Cl2N4O2

Molecular Weight

499.43

References & Citations

[1]Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5 (2) :108-17.|[2]Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :1916-20.|[3]Barclay Z, et al. Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT (2A) receptor. Cell Signal. 2013 Apr;25 (4) :814-21.