PIM1-IN-2

PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].

Product Specifications

CAS Number

[477845-12-8]

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pim1-in-2.html

Purity

99.0

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

NC1=NC=CC(C2=CC3=C(C4=CC=C(Cl)C=C4)ON=C3C=C2)=N1

Molecular Formula

C17H11ClN4O

Molecular Weight

322.75

References & Citations

[1]Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51 (6) :1972-5.