Psora-4
Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2].
Product Specifications
CAS Number
[724709-68-6]
Product Name Alternative
5- (4-Phenylbutoxy) psoralen
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/psora-4.html
Purity
99.7
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=C(OCCCCC3=CC=CC=C3)C4=C(OC=C4)C=C2O1
Molecular Formula
C21H18O4
Molecular Weight
334.37
Precautions
H315, H319, H335, H413
References & Citations
[1]Vennekamp J, et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65 (6) :1364-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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