RuBi-4AP

RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation[1][2].

Product Specifications

CAS Number

[851956-02-0]

UNSPSC

12352211

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rubi-4ap.html

Solubility

10 mM in DMSO

Smiles

NC1=CC=[N]([Ru+2]23([N]4=CC=CC=C4C5=CC=CC=[N]35)([N]6=CC=C(N)C=C6)[N]7=CC=CC=C7C8=CC=CC=[N]28)C=C1.[Cl-].[Cl-]

Molecular Formula

C30H28Cl2N8Ru

Molecular Weight

672.57

References & Citations

[1]Zayat L, et al. A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage. J Am Chem Soc. 2003 Jan 29;125 (4) :882-3.|[2]Rowan MJ, et al. Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J Neurosci. 2014 May 7;34 (19) :6611-23.