XE991
XE 991, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].
Product Specifications
CAS Number
122955-42-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xe991.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
Molecular Formula
C26H20N2O
Molecular Weight
376.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282 (5395) :1890-3.|[2]Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis (4-pyridinylmethyl) -9 (10H) -anthracenone and 10,10-bis (2-fluoro-4-pyridinylmethyl) -9 (10H) -anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285 (2) :724-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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