15-Deoxy-Δ-12,14-prostaglandin J2
Product Specifications
UNSPSC Description
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].
Target Antigen
Endogenous Metabolite; PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/15-Deoxy-Δ12,14-prostaglandin.html
Purity
99.0
Solubility
Ethanol : 75 mg/mL (ultrasonic;warming)
Smiles
CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O
Molecular Weight
316.43
References & Citations
[1]Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278.|[2]Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108568/15-Deoxy-12-14-prostaglandin-J2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108568/15-Deoxy-12-14-prostaglandin-J2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
87893-55-8
Curated Selection
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