15-Deoxy-Δ-12,14-prostaglandin J2

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

Product Specifications

CAS Number

[87893-55-8]

Product Name Alternative

15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Endogenous Metabolite; PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/15-Deoxy-Δ12,14-prostaglandin.html

Concentration

3.16 mM * 1 mL in Methyl acetate

Purity

99.0

Solubility

Ethanol : 75 mg/mL (ultrasonic; warming)

Smiles

CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O

Molecular Formula

C20H28O3

Molecular Weight

316.43

Precautions

H225, H319, H336

References & Citations

[1]Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13 (12) :3269-3278.|[2]Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83 (5) :813-9.