Q94 (hydrochloride)
Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation[1].
Product Specifications
CAS Number
1052076-77-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/q94-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(CN2C3=CC=CC=C3N=C2CC4=CC=CC=C4)C=C1.Cl
Molecular Formula
C21H18Cl2N2
Molecular Weight
369.29
Precautions
P261-P280-P302+P352
References & Citations
[1]Deng X, et al. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell. 2008 Jun;19 (6) :2520-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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