Q94 (hydrochloride)

Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation[1].

Product Specifications

CAS Number

[1052076-77-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/q94-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(CN2C3=CC=CC=C3N=C2CC4=CC=CC=C4)C=C1.Cl

Molecular Formula

C21H18Cl2N2

Molecular Weight

369.29

Precautions

P261-P280-P302+P352

References & Citations

[1]Deng X, et al. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell. 2008 Jun;19 (6) :2520-33.