L-AP3

L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1].

Product Specifications

CAS Number

[23052-80-4]

Product Name Alternative

3-Phosphono-L-alanine

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-ap3.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

N[C@@H](CP(O)(O)=O)C(O)=O

Molecular Formula

C3H8NO5P

Molecular Weight

169.07

Precautions

H302, H312, H332

References & Citations

[1]J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307 (2) :219-25.