Ethacrynic acid D5
Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs) . Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].
Product Specifications
CAS Number
1330052-59-9
UNSPSC
12352005
Hazard Statement
H302+H312+H332-H315-H319-H335
Target
Calcium Channel; Glutathione S-transferase; NF-κB
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C(O)COC1=CC=C(C(C(C([2H])([2H])C([2H])([2H])[2H])=C)=O)C(Cl)=C1Cl
Molecular Formula
C13H7D5Cl2O4
Molecular Weight
308.17
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Frequently Asked Questions
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