PMX464

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].

Product Specifications

CAS Number

[485842-97-5]

Product Name Alternative

AW 464

UNSPSC

12352005

Target

TrxR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pmx464.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CC(O)(C2=NC3=CC=CC=C3S2)C=C1

Molecular Formula

C13H9NO2S

Molecular Weight

243.28

References & Citations

[1]Callister ME, et, al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol. 2008 Nov;155 (5) :661-72.