TC-E 5001

TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2].

Product Specifications

CAS Number

[865565-29-3]

UNSPSC

12352005

Target

PARP; Wnt

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tc-e-5001.html

Solubility

10 mM in DMSO

Smiles

CC1=NN=C(SCC2=NC(C3=CC=C(OC)C=C3)=NO2)N1C4=CC=C(OC)C=C4

Molecular Formula

C20H19N5O3S

Molecular Weight

409.46

References & Citations

[1]Shultz MD, et, al. [1,2,4]triazol-3-ylsulfanylmethyl) -3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem. 2012 Feb 9;55 (3) :1127-36.|[2]Lien VT, et, al. Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. 2019 Jour; 9 (63) : 37092-37100.