KC 12291 (hydrochloride)
Product Specifications
UNSPSC Description
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].
Target Antigen
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kc-12291-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.CN(CCCOC1=NSC(C2=CC=CC=C2)=N1)CCC3=CC=C(OC)C(OC)=C3
Molecular Weight
449.99
References & Citations
[1]John GW, et al. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc Drug Rev. 2004 Spring;22(1):17-26.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108502/KC-12291-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108502/
Clinical Information
No Development Reported
CAS Number
181936-98-1
Curated Selection
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