KC 12291 (hydrochloride)

KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC) . KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].

Product Specifications

CAS Number

[181936-98-1]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kc-12291-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.CN(CCCOC1=NSC(C2=CC=CC=C2)=N1)CCC3=CC=C(OC)C(OC)=C3

Molecular Formula

C22H28ClN3O3S

Molecular Weight

449.99

References & Citations

[1]John GW, et al. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc Drug Rev. 2004 Spring;22 (1) :17-26.