Z-L (D-Val) G-CHN2

Z-L (D-Val) G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137) . Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3].

Product Specifications

UNSPSC

12352005

Target

Cathepsin; HSV; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/z-l-d-val-g-chn2.html

Purity

99.35

Solubility

DMSO : 4.5 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(NCC(C=[N+]=[N-])=O)=O)C(C)C)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O

Molecular Formula

C22H31N5O5

Molecular Weight

445.51

References & Citations

[1]R L Mellgren, et al. Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp Cell Res. 1994 Nov;215 (1) :164-71.|[2]L Björck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus. J Virol|[3]Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016.