LY2881835

LY2881835 is a potent and selective agonist of G protein-coupled receptor 40 (GPR40) . LY2881835 has efficacious and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. LY2881835 has the potential for the research of type 2 diabetes mellitus[1]. LY2881835 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1292290-38-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Free Fatty Acid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ly2881835.html

Solubility

10 mM in DMSO

Smiles

OC(C[C@H](C#CC)C(C=C1)=CC=C1OCC(C=C2)=CC=C2CN3CCC4(CC3)C5=CC=CC=C5C=C4)=O

Molecular Formula

C33H33NO3

Molecular Weight

491.62

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Hamdouchi C, et al. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470) . J Med Chem. 2016;59 (24) :10891-10916.