TAP311
TAP311 is a cholesteryl ester transfer protein (CETP) inhibitor with an IC50 of 62 nM[1].
Product Specifications
CAS Number
1149362-88-8
UNSPSC
12352005
Target
CETP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tap311.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC(CN([C@@H]2C[C@H](CC)N(C(O[C@@H]3CC[C@@H](C(O)=O)CC3)=O)[C@H](CC)C2)C4=NC=C(C5=CN(C)N=C5)C=N4)=CC(C(F)(F)F)=C1
Molecular Formula
C34H40F6N6O4
Molecular Weight
710.71
References & Citations
[1]Yamada K, et al. Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. J Med Chem. 2017 Oct 26;60 (20) :8466-8481.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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