Aminoxyacetic acid
Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.
Product Specifications
CAS Number
[645-88-5]
Product Name Alternative
Carboxymethoxylamine; Aminooxyacetate
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aminoxyacetic-acid.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O=C(O)CON
Molecular Formula
C2H5NO3
Molecular Weight
91.07
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378 (1) :1-7.|[2]Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322 (3) :210-5.|[3]Korangath P, et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21 (14) :3263-73.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Stem Cell Res Ther. 2025 Oct 31;16 (1) :603.|Am J Transl Res. 2018 Dec 15;10 (12) :4247-4257.|ASN Neuro. 2021 Jan-Dec:13:17590914211043087.|Biomed Pharmacother. 2023 Nov:167:115605.|bioRxiv. 2025 July 11.|Cancer Res. 2022 Sep 16;82 (18) :3223-3235.|Cell Death Discov. 2025 Oct 6;11 (1) :430.|Cell Mol Life Sci. 2024 May 3;81 (1) :204.|CNS Neurosci Ther. 2023 Mar;29 (3) :941-956.|Comput Biol Med. 2023 Oct:165:107415.|J Virol. 2025 Nov 25;99 (11) :e0098525.|Mol Nutr Food Res. 2023 Nov;67 (22) :e2300112.|Nat Metab. 2022 Feb;4 (2) :239-253.|Phytomedicine. 2025 Nov 25:148:157492.|Redox Biol. 2024 May:71:103112.|Research (Wash D C) . 2025 May 23:8:0703.|Sci Adv. 2025 Aug 15;11 (33) :eadw9241.|Sci Adv. 2025 Aug 29;11 (35) :eadu6271.|Signal Transduct Target Ther. 2023 Feb 15;8 (1) :65.|Theranostics. 2021 Mar 24;11 (12) :5650-5674.|Viruses. 2024 Sep 29;16 (10) :1540.
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items