Eplivanserin
Eplivanserin (SR-46349) is a potent, selective and orally active 5-HT2A receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Eplivanserin displays >20-fold selectivity more selective for 5-HT2A than 5-HT2B and 5-HT2C[1][2].
Product Specifications
CAS Number
[130579-75-8]
Product Name Alternative
SR-46349
UNSPSC
12352005
Hazard Statement
H302-H410
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Eplivanserin.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(/C=C/C(C2=CC=CC=C2F)=N/OCCN(C)C)C=C1
Molecular Formula
C19H21FN2O2
Molecular Weight
328.39
Precautions
P264-P270-P273-P330-P391-P501
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10792/Eplivanserin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10792/
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT2 Receptor; α-1 microglobulin
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