Theophylline (sodium glycinate)

Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

Product Specifications

CAS Number

[8000-10-0]

Product Name Alternative

1,3-Dimethylxanthine (sodium glycinate) ; Theo-24 (sodium glycinate)

UNSPSC

12352005

Target

Adenosine Receptor; Apoptosis; HDAC; Interleukin Related; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/theophylline-sodium-glycinate.html

Solubility

10 mM in DMSO

Smiles

NCC(O)=O.O=C(N1C)C2=C(NC=N2)N(C)C1=O.[Na+]

Molecular Formula

C9H13N5NaO4+

Molecular Weight

278.22

References & Citations

[1]Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8 (4) :637-42.|[2] Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7 (5) :371-5.|[3]Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99 (13) :8921-6.|[4] Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188 (8) :901-6.