N-Acetyl-5-hydroxytryptamine-d3

N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].

Product Specifications

CAS Number

[2001098-07-1]

Product Name Alternative

N-Acetylserotonin-d3; Normelatonin-d3; O-Demethylmelatonin-d3

UNSPSC

12352005

Target

Endogenous Metabolite; Trk Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Neurological Disease

Purity

99.04

Solubility

10 mM in DMSO|DMSO : 100mg/mL (ultrasonic)

Smiles

[2H]C([2H])([2H])C(NCCC(C1=C2)=CNC1=CC=C2O)=O

Molecular Formula

C12H11D3N2O2

Molecular Weight

221.27

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Jang SW, et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A. 2010 Feb 23;107 (8) :3876-81.