K-Ras (G12C) inhibitor 6
K-Ras (G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras (G12C) [1].
Product Specifications
CAS Number
2060530-16-5
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-ras-g12c-inhibitor-6.html
Purity
99.08
Solubility
10 mM in DMSO
Smiles
ClC1=C(OCC(N2CCC(NC(CCCS)=O)CC2)=O)C=CC(Cl)=C1
Molecular Formula
C17H22Cl2N2O3S
Molecular Weight
405.34
References & Citations
[1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Frequently Asked Questions
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