K-Ras (G12C) inhibitor 6

K-Ras (G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras (G12C) [1].

Product Specifications

CAS Number

[2060530-16-5]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/k-ras-g12c-inhibitor-6.html

Purity

99.08

Solubility

10 mM in DMSO

Smiles

ClC1=C(OCC(N2CCC(NC(CCCS)=O)CC2)=O)C=CC(Cl)=C1

Molecular Formula

C17H22Cl2N2O3S

Molecular Weight

405.34

References & Citations

[1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-51.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

Available Sizes

Curated Selection

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