Antibiotic DC 81

Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine) . Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct[1][2].

Product Specifications

CAS Number

[81307-24-6]

Product Name Alternative

DC 81

UNSPSC

12352005

Target

Antibiotic; Apoptosis; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antibiotic-dc-81.html

Solubility

H2O

Smiles

O=C1C2=CC(OC)=C(O)C=C2N=C[C@@]3([H])N1CCC3

Molecular Formula

C13H14N2O3

Molecular Weight

246.26

References & Citations

[1]Hu WP, et al. Biological evaluation of an antibiotic DC-81-indole conjugate agent in human melanoma cell lines. Kaohsiung J Med Sci. 2003 Jan;19 (1) :6-12. |[2]Lee CH, et al. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. Chem Biol Interact. 2009 Aug 14;180 (3) :360-7.