JMV 390-1
JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT) /neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium[1].
Product Specifications
CAS Number
148473-36-3
UNSPSC
12352005
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jmv-390-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(O)=O)CC(C)C)[C@H]([C@@H](C)CC)NC([C@@H](CC(NO)=O)CC1=CC=CC=C1)=O
Molecular Formula
C23H35N3O6
Molecular Weight
449.54
References & Citations
[1]Doulut S, et al. Synthesis and analgesic effects of N-[3-[ (hydroxyamino) carbonyl]-1-oxo-2 (R) -benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J Med Chem. 1993 May 14;36 (10) :1369-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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