Y-29794 (oxalate)

Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM) [1][2][3].

Product Specifications

CAS Number

[146794-84-5]

UNSPSC

12352005

Target

Prolyl Endopeptidase (PREP)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/y-29794-oxalate.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CS1)C2=C(N=C(C(C)C)C=C2)SCCCCCCCCN(C)C.OC(C(O)=O)=O

Molecular Formula

C25H36N2O5S2

Molecular Weight

508.69

References & Citations

[1]Perez RE, et al. Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Nov 1;21 (11) :1033-1040.|[2]Kato A, et al. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J Pharmacol Exp Ther. 1997 Oct;283 (1) :328-35.|[3]Nakajima T, et al. Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141 (2) :156-60.