GR 89696 (free base)
GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].
Product Specifications
CAS Number
126766-31-2
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gr-89696-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C(CN2CCCC2)C1)C(CC3=CC=C(C(Cl)=C3)Cl)=O)OC
Molecular Formula
C19H25Cl2N3O3
Molecular Weight
414.33
References & Citations
[1]Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328 (1) :193-200. |[2]A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21 (2) :105-13
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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