Lu AA33810
Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1][2].
Product Specifications
CAS Number
304008-29-5
UNSPSC
12352005
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lu-aa33810.html
Purity
98.3
Solubility
DMSO : 42.36 mg/mL (ultrasonic; warming)
Smiles
CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O
Molecular Formula
C19H25N3O2S3
Molecular Weight
423.62
References & Citations
[1]Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[ (4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl) amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328 (3) :900-11. |[2]Domin H, et al. Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Psychopharmacology (Berl) . 2017 Feb;234 (4) :631-645.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y5 receptor
Available Sizes
Frequently Asked Questions
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