Lu AA33810

Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1][2].

Product Specifications

CAS Number

[304008-29-5]

UNSPSC

12352005

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lu-aa33810.html

Purity

98.3

Solubility

DMSO : 42.36 mg/mL (ultrasonic; warming)

Smiles

CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O

Molecular Formula

C19H25N3O2S3

Molecular Weight

423.62

References & Citations

[1]Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[ (4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl) amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328 (3) :900-11. |[2]Domin H, et al. Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Psychopharmacology (Berl) . 2017 Feb;234 (4) :631-645.