LY 233053

LY 233053 is a potent and competitive NMDA-receptor antagonist with anticonvulsant and antiepileptic efficacy[1][2].

Product Specifications

CAS Number

[125546-04-5]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly-233053.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](NCC1)C[C@@H]1CC2=NN=NN2)=O

Molecular Formula

C8H13N5O2

Molecular Weight

211.22

References & Citations

[1]1.K K Borowicz, et al. Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia. 1996 Jul;37 (7) :618-24. |[2]K P Madden, et al. Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J Neurosurg. 1992 Jan;76 (1) :106-10.