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Threo-Ifenprodil (hemitartrate)

Threo Ifenprodil hemitartrate is a σ receptor agonist, with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist (IC50=0.22 μM) . threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC 50 of 88 nM, showing antiarrhythmic activity[1][2][3].

Product Specifications

CAS Number

1312991-83-5

UNSPSC

12352005

Target

IGluR; Potassium Channel; Sigma Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/threo-ifenprodil-hemitartrate.html

Solubility

10 mM in DMSO

Smiles

OC([C@H](O)[C@@H](O)C(O)=O)=O.O[C@H](C1=CC=C(C=C1)O)[C@@H](C)N(CC2)CCC2CC3=CC=CC=C3.[1/2]

Molecular Formula

C21H27NO2.1/2C4H6O6

Molecular Weight

400.50

References & Citations

[1]Hashimoto K, et al. Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of sigma receptors. Eur J Pharmacol. 1995 Feb 6;273 (3) :307-10.|[2]Avenet P, et al. Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes. Eur J Pharmacol. 1996 Jan 25;296 (2) :209-13.|[3]Monassier L, et al. sigma (2) -receptor ligand-mediated inhibition of inwardly rectifying K (+) channels in the heart. J Pharmacol Exp Ther. 2007 Jul;322 (1) :341-50.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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