Ro 04-5595 (hydrochloride)
Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM) [1].
Product Specifications
CAS Number
64047-73-0
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-04-5595-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C1)=CC=C1CCC2C3=CC(O)=C(OC)C=C3CCN2C.Cl
Molecular Formula
C19H23Cl2NO2
Molecular Weight
368.30
References & Citations
[1]Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70 (5) :2147-55. |[2]Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42 (7) :1539-1547. |[3]deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40 (2) :394-405.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
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