UB-165 (fumarate)
Product Specifications
CAS Number
2454492-43-2
UNSPSC Description
UB-165 fumarate is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for [3H]-nicotine binding in rat brain[1].
Target Antigen
nAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ub-165-fumarate.html
Solubility
10 mM in DMSO
Smiles
ClC1=NC=C(C2=CCC[C@@]3([H])N[C@]2([H])CC3)C=C1.O=C(O)/C=C/C(O)=O
Molecular Weight
350.80
References & Citations
[1]Christopher G. V. Sharples, et al. UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes. Journal of Neuroscience 15 April 2000, 20 (8) 2783-2791.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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