5-Iodo-A-85380 (dihydrochloride)
5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with Kds of 12 and 14 pM, respectively[1].
Product Specifications
CAS Number
[1217837-17-6]
Product Name Alternative
5-I A-85380 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-iodo-a-85380-dihydrochloride.html
Purity
98.97
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
IC1=CC(OC[C@@H]2CCN2)=CN=C1.[H]Cl.[H]Cl
Molecular Formula
C9H13Cl2IN2O
Molecular Weight
363.02
Precautions
H302
References & Citations
[1]Mukhin AG, et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol. 2000 Mar;57 (3) :642-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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