5-Iodo-A-85380 (dihydrochloride)

5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with Kds of 12 and 14 pM, respectively[1].

Product Specifications

CAS Number

[1217837-17-6]

Product Name Alternative

5-I A-85380 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-iodo-a-85380-dihydrochloride.html

Purity

98.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

IC1=CC(OC[C@@H]2CCN2)=CN=C1.[H]Cl.[H]Cl

Molecular Formula

C9H13Cl2IN2O

Molecular Weight

363.02

Precautions

H302

References & Citations

[1]Mukhin AG, et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol. 2000 Mar;57 (3) :642-9.