TC-1698
TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer's disease research[1].
Product Specifications
CAS Number
700834-58-8
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc-1698.html
Solubility
10 mM in DMSO
Smiles
N1(CC2)C(C3=CC=CN=C3)CCC2CC1
Molecular Formula
C13H18N2
Molecular Weight
202.30
References & Citations
[1]Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54 (23) :7943-61.|[2]Marrero MB, et al. The neuroprotective effect of 2- (3-pyridyl) -1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309 (1) :16-27.|[3]Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524 (1-3) :11-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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