MIF-1

MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) [1][2][3].

Product Specifications

CAS Number

[2002-44-0]

Product Name Alternative

Pro-Leu-Gly-NH2; Melanostatin

UNSPSC

12352209

Hazard Statement

H315-H319-H320

Target

Dopamine Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mif-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC(N)=O)[C@H](CC(C)C)NC([C@@H]1CCCN1)=O

Molecular Formula

C13H24N4O3

Molecular Weight

284.35

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Bocheva A, et, al. Antiopioid properties of the TYR-MIF-1 family. Methods Find Exp Clin Pharmacol. 2004 Nov;26 (9) :673-7.|[2]Valentijn JA, et, al. Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. J Physiol. 1994 Mar 1;475 (2) :185-95.|[3]Saleh MI, et, al. MIF-1 attenuates spiroperidol alteration of striatal dopamine D2 receptor ontogeny. Peptides. 1989 Jan-Feb;10 (1) :35-9.