PTAC (oxalate)

PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells) . PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].

Product Specifications

CAS Number

[201939-40-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ptac-oxalate.html

Solubility

10 mM in DMSO

Smiles

CCCSC1=NSN=C1[C@@H]2[C@@H]3C[N@@](CCC3)C2.OC(C(O)=O)=O

Molecular Formula

C14H21N3O4S2

Molecular Weight

359.46

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]F P Bymaster, et al. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R) 6- (3-propylthio-1,2,5-thiadiazol-4-yl) -1-azabicyclo[3.2.1]octane. Eur J Pharmacol. 1998 Sep 4;356 (2-3) :109-19.|[2] (5R,6R) 6- (3-Propylthio-1,2,5-thiadiazol-4-yl) -1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr;124 (4) :1330-1338.