ONO-4817
ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP) . Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit[1].
Product Specifications
CAS Number
223472-31-9
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ono-4817.html
Purity
98.94
Solubility
DMSO : 125 mg/mL (ultrasonic) |Ethanol : 15 mg/mL (ultrasonic)
Smiles
ONC([C@@H](C)C[C@@H](COCOCC)NC(C(C=C1)=CC=C1OC2=CC=CC=C2)=O)=O
Molecular Formula
C22H28N2O6
Molecular Weight
416.47
References & Citations
[1]Okamoto Y, et al. A matrix metalloproteinase inhibitor, ONO-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. Int Heart J. 2007;48 (3) :369-378.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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