ONO-4817

ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP) . Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit[1].

Product Specifications

CAS Number

[223472-31-9]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ono-4817.html

Purity

98.94

Solubility

DMSO : 125 mg/mL (ultrasonic) |Ethanol : 15 mg/mL (ultrasonic)

Smiles

ONC([C@@H](C)C[C@@H](COCOCC)NC(C(C=C1)=CC=C1OC2=CC=CC=C2)=O)=O

Molecular Formula

C22H28N2O6

Molecular Weight

416.47

References & Citations

[1]Okamoto Y, et al. A matrix metalloproteinase inhibitor, ONO-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. Int Heart J. 2007;48 (3) :369-378.