Leukotriene B4

Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].

Product Specifications

CAS Number

[71160-24-2]

Product Name Alternative

LTB4; 5 (S),12 (R) -DiHETE

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Endogenous Metabolite; Leukotriene Receptor; PROTAC Linkers

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/5,12-DiHETE.html

Concentration

297.2 μM * 250 μL in Ethanol

Purity

98.0

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O

Molecular Formula

C20H32O4

Molecular Weight

336.47

Precautions

H225, H319

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562|[2]S.WCrooks, et al. Leukotriene B4. The International Journal of Biochemistry & Cell Biology Volume 30, Issue 2, 27 March 1998, Pages 173-178.|[3]Takehiko Yokomizo, et al. Leukotriene B4: Metabolism and Signal Transduction. Archives of Biochemistry and Biophysics Volume 385, Issue 2, 15 January 2001, Pages 231-241.