PS-1145 (dihydrochloride)
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].
Product Specifications
CAS Number
[1049743-58-9]
UNSPSC
12352005
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ps-1145-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4.[H]Cl.[H]Cl
Molecular Formula
C17H13Cl3N4O
Molecular Weight
395.67
References & Citations
[1]Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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